Stroke, Acute (Cerebrovascular Accident [CVA])
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The sudden onset of a focal neurologic deficit(s) resulting from either infarction or hemorrhage within the brain
- Two broad categories: ischemic (thrombotic or embolic) (87%) and hemorrhagic (13%)
- Hemorrhage can be intracerebral or subarachnoid.
- System(s) affected: neurologic; vascular (1)
- Synonym(s): CVA; cerebral infarct
- Related terms: transient ischemic attack (TIA), a transient episode of neurologic dysfunction due to focal ischemia without permanent infarction on imaging (see topic “Transient Ischemic Attack (TIA)”)
- Incidence: 2 to 13/100,000
- Frequent risk factors: arteriopathies (53%), cardiac disorders (31%), and infection (24%) (2)
Annual incidence in the United States is ~795,000.
- Prevalence in the United States: 550/100,000
- Predominant age: Risk increases >45 years of age and is highest during the 7th and 8th decades.
- Predominant sex: male > female at younger age but higher incidence in women with age ≥75 years
Etiology and Pathophysiology
- 87% of strokes are ischemic, three main subtypes: thrombosis, embolism, and systemic hypoperfusion. Large vessel atherothrombotic strokes often involve the origin of the internal carotid artery. Small vessel lacunar strokes are commonly due to lipohyalinotic occlusion. Embolic strokes are largely from a cardiac source (due to left atrial thrombus, atrial fibrillation, recent MI, valve disease, or mechanical valves) or ascending aortic atheromatous disease (>4 mm) (1).
- 13% of strokes are hemorrhagic; most commonly due to hypertension. Other causes include intracranial vascular malformations (cavernous angiomas, AVMs), cerebral amyloid angiopathy (lobar hemorrhages in elderly), and anticoagulation (1).
- Fibromuscular dysplasia (rare), vasculitis, or drug use (cocaine, amphetamines) are other causes of stroke.
Stroke is a polygenic multifactorial disease.
- Uncontrollable: age, gender, race, family history/genetics, prior stroke or TIA
- Metabolic: diabetes, dyslipidemia
- Lifestyle: smoking, cocaine and amphetamine use
- Cardiovascular: hypertension, atrial fibrillation, valvular heart disease, endocarditis, recent MI, severe carotid artery stenosis, hypercoagulable states, and patent foramen ovale (1)
Smoking cessation, regular exercise, weight control to maintain nonobese BMI and prevent type 2 diabetes, moderate alcohol use; control BP; manage hyperlipidemia; use antiplatelet agent (e.g., aspirin) in high-risk persons; treat nonvalvular atrial fibrillation with dose-adjusted warfarin or dabigatran, apixaban, and rivaroxaban (3).
Commonly Associated Conditions
Coronary artery disease is the major cause of death during the first 5 years after a stroke.