Vincent Stomatitis
Basics
A distinct form of periodontal disease due to inflammatory infection of the gingiva, characterized by pain, ulcerations, and necrotizing damage to interdental papillae
Description
- Caused by an imbalance of oral flora, resulting in a predominance of anaerobic bacteria that invade the gingival mucosa and form a gray pseudomembranous exudate
- Clinical presentation includes oral pain, fetid breath, gingival ulcerations, necrosis, and bleeding
- Differentiated from other periodontal diseases by rapid onset, pain, ulcerated gingival mucosa, and “punched out” crater-like lesions of interdental papillae (1)
- The most common bacteria include Fusobacterium spp., Prevotella intermedia, and spirochetes. Concomitant infection with Epstein-Barr virus, herpes simplex virus, and type 1 human cytomegalovirus is common.
- Synonym(s): Vincent angina; Vincent disease; trench mouth; fusospirochetal gingivitis; acute necrotizing ulcerative gingivitis (ANUG); necrotizing ulcerative gingivitis (NUG)
- Necrotizing gingivitis, necrotizing periodontitis, and necrotizing stomatitis are classified together under the umbrella term “necrotizing periodontal disease (NPD).” Necrotizing gingivitis is confined to the gingiva without a loss of peridontal attachment or alveolar bone support.
Epidemiology
Incidence
- Predominant age: 18 to 30 years in developed countries, malnourished children ages 3 to 14 years
- Affects both genders with similar frequency
- Historically, incidence increased in military personnel due to poor battlefield conditions and psychological stress (1)
Prevalence
- The true prevalence is unknown but likely <1% overall (1).
- Worldwide prevalence has declined since World War II (1).
- A rare disease in developed countries; however, in recent data, prevalence rate was 6.7% in Chilean students between ages 12 and 21 years and approaching 25% in children in sub-Saharan African countries (2),(3).
Etiology and Pathophysiology
- Impaired host immunologic response due to immunocompromised state or malnutrition
- Disruption of normal oral flora with a predominance of invasive anaerobic bacteria (Treponema spp., Selenomonas spp., Fusobacterium spp., and Prevotella intermedia) (2)
- Endogenous bacteria produce metabolites such as collagenase, endotoxins, and fibrinolysin that destroy tissue, leading to loss of integrity and necrosis of the gingival mucosa and interdental papillae (4).
- Stress increases adrenocortical hormones and reduces gingival microcirculation and salivary flow, which alters leukocyte and lymphocyte function. Stress may also result in behavioral changes that lead to poor oral hygiene and malnutrition (2).
- Increased bacterial attachment with active herpesvirus infection
Risk Factors
- Malnutrition
- Immunosuppression (diabetes, alcohol use, HIV, cancer, chemotherapy, steroid use)
- Low socioeconomic status
- Tobacco use
- Poor oral hygiene, infrequent or absent dental care
- Orthodontics
- Herpesvirus infection
- Psychological stress
General Prevention
- Appropriate nutrition
- Proper oral hygiene
- Regular dental care
- Prompt recognition and institution of therapy
- Management of medical problems such as cancer and HIV infection
- Smoking cessation
- Stress management
Commonly Associated Conditions
- Most commonly seen in malnourished patients, patients undergoing cancer treatment, or those from underdeveloped countries
- Bacteremia
- Tooth loss
- Chronic gingivitis
- Noma (cancrum oris), a gangrenous infection of the oral mucosa
- Aspiration pneumonia
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Citation
Domino, Frank J., et al., editors. "Vincent Stomatitis." 5-Minute Clinical Consult, 33rd ed., Wolters Kluwer, 2025. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117674/all/Vincent_Stomatitis.
Vincent Stomatitis. In: Domino FJF, Baldor RAR, Golding JJ, et al, eds. 5-Minute Clinical Consult. Wolters Kluwer; 2025. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117674/all/Vincent_Stomatitis. Accessed December 3, 2024.
Vincent Stomatitis. (2025). In Domino, F. J., Baldor, R. A., Golding, J., & Stephens, M. B. (Eds.), 5-Minute Clinical Consult (33rd ed.). Wolters Kluwer. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117674/all/Vincent_Stomatitis
Vincent Stomatitis [Internet]. In: Domino FJF, Baldor RAR, Golding JJ, Stephens MBM, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2025. [cited 2024 December 03]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117674/all/Vincent_Stomatitis.
* Article titles in AMA citation format should be in sentence-case
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T1 - Vincent Stomatitis
ID - 117674
ED - Domino,Frank J,
ED - Baldor,Robert A,
ED - Golding,Jeremy,
ED - Stephens,Mark B,
BT - 5-Minute Clinical Consult, Updating
UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117674/all/Vincent_Stomatitis
PB - Wolters Kluwer
ET - 33
DB - Medicine Central
DP - Unbound Medicine
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