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Granuloma, Pyogenic

Granuloma, Pyogenic is a topic covered in the 5-Minute Clinical Consult.

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  • Pyogenic granulomas (PG), also called lobular capillary hemangiomas, are benign vascular proliferations that can appear on the skin and mucus membranes. Most common sites are head and neck, the lips and oral cavity, the trunk, and the extremities (1).
  • They are friable and tend to bleed profusely due to the vascular nature of the lesion.
  • Smooth, red to purple, sessile or pedunculated, grow rapidly over several weeks
  • Rarely regress without intervention


  • The peak incidence of PG occurs in the 2nd and 3rd decades of life (2).
  • Commonly seen in early pregnancy

Etiology and Pathophysiology

  • Definitive cause unknown
  • Thought to be associated with capillary proliferation resulting from aberrant healing response to minor trauma
  • Associated with peripheral nerve injury, inflammatory systemic diseases, and drugs (retinoids, systemic steroids, protease inhibitors, epidermal growth factor receptor inhibitors)
  • May be related to hormonal changes in pregnancy
  • Not considered a hemangioma or neoplasm; no true granulomatous histology present

Risk Factors

  • Pregnancy
  • Trauma
  • Intraoral trauma or surgery
  • Inflammatory systemic diseases

General Prevention

Good oral hygiene may be helpful.

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Stephens, Mark B., et al., editors. "Granuloma, Pyogenic." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2019. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117493/all/Granuloma__Pyogenic.
Granuloma, Pyogenic. In: Stephens MB, Golding J, Baldor RA, et al, eds. 5-Minute Clinical Consult. 27th ed. Wolters Kluwer; 2019. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117493/all/Granuloma__Pyogenic. Accessed April 25, 2019.
Granuloma, Pyogenic. (2019). In Stephens, M. B., Golding, J., Baldor, R. A., & Domino, F. J. (Eds.), 5-Minute Clinical Consult. Available from https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117493/all/Granuloma__Pyogenic
Granuloma, Pyogenic [Internet]. In: Stephens MB, Golding J, Baldor RA, Domino FJ, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2019. [cited 2019 April 25]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117493/all/Granuloma__Pyogenic.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Granuloma, Pyogenic ID - 117493 ED - Stephens,Mark B, ED - Golding,Jeremy, ED - Baldor,Robert A, ED - Domino,Frank J, BT - 5-Minute Clinical Consult, Updating UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117493/all/Granuloma__Pyogenic PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -