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Pancreatitis, Chronic

Pancreatitis, Chronic is a topic covered in the 5-Minute Clinical Consult.

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Basics

Description

  • Long-standing and progressive destruction of pancreatic tissue due to persistent inflammation
  • Results in exocrine and/or endocrine insufficiency
  • Major features
    • Pain
    • Malabsorption
    • Diabetes mellitus (type 3)
    • Increased risk of pancreatic cancer

Epidemiology

Incidence

Predominant age: 35 to 45 years (usually related to alcohol abuse)

  • Predominant sex: male > female
  • Hospitalization more common for blacks than whites

Prevalence
8/10,000

Genetics
Hereditary pancreatitis is a rare condition with an autosomal dominant inheritance pattern; mutations in PRSS1 gene and SPINKI gene

General Prevention

  • Avoid tobacco.
  • Avoid excess alcohol.

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Citation

Stephens, Mark B., et al., editors. "Pancreatitis, Chronic." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2019. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117286/all/Pancreatitis__Chronic.
Pancreatitis, Chronic. In: Stephens MB, Golding J, Baldor RA, et al, eds. 5-Minute Clinical Consult. 27th ed. Wolters Kluwer; 2019. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117286/all/Pancreatitis__Chronic. Accessed April 18, 2019.
Pancreatitis, Chronic. (2019). In Stephens, M. B., Golding, J., Baldor, R. A., & Domino, F. J. (Eds.), 5-Minute Clinical Consult. Available from https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117286/all/Pancreatitis__Chronic
Pancreatitis, Chronic [Internet]. In: Stephens MB, Golding J, Baldor RA, Domino FJ, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2019. [cited 2019 April 18]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117286/all/Pancreatitis__Chronic.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Pancreatitis, Chronic ID - 117286 ED - Stephens,Mark B, ED - Golding,Jeremy, ED - Baldor,Robert A, ED - Domino,Frank J, BT - 5-Minute Clinical Consult, Updating UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117286/all/Pancreatitis__Chronic PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -