Glaucoma, Primary Closed-Angle
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Glaucoma is a progressive decline in vision that is usually associated with elevated intraocular pressure (IOP) in the eye, which leads to damage of the optic nerve. Primary angle closure (PAC) is one reason for glaucoma and can be classified as the following:
- Primary angle-closure suspect (PACS) is >180 degrees of iridotrabecular contact (ITC), normal IOP with no optic nerve damage.
- PAC is >180 degrees ITC with peripheral anterior synechiae (PAS) or elevated IOP but with no optic neuropathy.
- Primary angle-closure glaucoma (PACG) is >180-degree ITC with PAS, elevated IOP, and optic neuropathy.
Acute angle-closure crisis (AACC) is when the angle is occluded with symptomatic high IOP; it is a medical emergency requiring prompt treatment.
- Plateau iris configuration is any ITC persisting after a patent laser peripheral iridotomy (LPI) or a plateau iris syndrome which is any ITC persisting after a patent LPI with pressure elevation after dilation.
Increased risk with age and prior history of cataract, hyperopia, and/or uveitis
Medications used may cross the placenta and be excreted into breast milk. Majority of IOP-lowering medications are within class C, and the risk of adverse effects to the fetus must be balanced with risk of vision loss in the mother.
- Older age
- Female sex
- More likely in those of Inuit and East or South Asian descent
In 2013, it is estimated to have a worldwide prevalence of 20.2 million people aged 40 to 80 years with majority (15.5 million) in Asia (1). PACG is not as common in the United States; accounts for 10% of all glaucoma
Etiology and Pathophysiology
- PAC happens when iris touches the trabecular meshwork at the anterior chamber angle called ITC. ITC causes obstruction of aqueous humor outflow through the trabecular meshwork, which causes elevation in IOP. Prolonged ITC can cause scarring, degradation of trabecular meshwork, and loss of vision (1).
- Most common underlying mechanism of angle closure is pupillary blockage of the aqueous flow from posterior to anterior chamber. This causes increase in pressure in the posterior chamber as compared to the anterior chamber. The buildup of pressure in the posterior chamber leads to anterior bowing of the iris and closing of the angle (1,2).
- Other mechanisms include predisposing ocular anatomy, such as plateau iris configuration (2).
First-degree relatives have a 1–12% increased risk in whites; 6 times greater risk in Chinese patients with positive family history
- Age >50 years
- Female gender
- Asian or Inuit descent
- Family history of angle closure
- Shallow anterior chamber
- Short axial length
- Thick crystalline lens
- Anterior positioned lens
- Plateau iris
- Drugs that can induce angle closure:
- Adrenergic agonists (albuterol, phenylephrine), anticholinergics (oxybutynin, atropine, botulinum toxin A), topiramate, antihistamines, antidepressants including selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), sulfa-based drugs, cocaine, ecstasy
Commonly Associated Conditions
- Systemic hypertension