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Syphilis is a topic covered in the 5-Minute Clinical Consult.

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  • A chronic, systemic infectious disease caused by Treponema pallidum
  • Transmitted sexually by direct contact with an active lesion, vertically (maternal–fetal), and via blood transfusions
  • Untreated disease includes four overlapping stages.
    • Primary: single (usually) painless chancre at point of entry; appears in 10 to 90 days; chancre heals without treatment in 3 to 6 weeks.
    • Secondary: appears 2 to 8 weeks after primary chancre; nonpruritic rash on palms or soles of feet, mucous membrane lesions, headache, fever, lymphadenopathy, alopecia
    • Latent: seroreactive without evidence of disease
      • Early latent: acquired within the last year
      • Late latent: exposure >12 months prior to diagnosis
    • Tertiary (late): Serology may be negative (fluorescent treponemal antibody absorption [FTA-ABS] test typically positive)
      • Gumma, cardiovascular, and late neurosyphilis; may be fatal
    • Neurosyphilis: any type of CNS involvement; can occur at any stage
      • Psychosis, delirium, dementia
  • Syphilis can affect nearly every organ/tissue

Pediatric Considerations
In noncongenital cases, consider child abuse.

Pregnancy Considerations
  • Screen all pregnant patients with venereal disease research laboratory (VDRL) test or rapid plasma reagin (RPR) test early in pregnancy. If high risk, repeat at 28 weeks and at delivery (1,2)[A].
  • Use the same nontreponemal test used for initial screening and for follow-up (1,2)[A].


  • Syphilis rate decreased until 2000; has since increased (primarily in men who have sex with men-MSM) (3)[A]
  • Syphilis rates increased 19% from 2014 to 2015 (7.5/100,000); highest for men aged 25 to 29 years and women aged 20 to 24 years (3)[A]
    • Men: 14/100,000
    • Women: 1.4/100,000
  • Congenital: 12/100,000 live births (3)[A]
  • Ocular: estimated to be 0.65% of syphilis cases
  • Primary and secondary syphilis rates (3)[A]
    • Male (per 100,000 population)
      • Whites, non-Hispanic: 7.6
      • Blacks, non-Hispanic: 39.0
      • Hispanics: 16.6
      • Asians: 5.9
      • American Indians/Alaska natives: 9.1
      • Native Hawaiians/Pacific Islanders: 19.1
      • Multirace: 10.6
    • Female (per 100,000 population)
      • Whites, non-Hispanic: 0.6
      • Blacks, non-Hispanic: 5.3
      • Hispanics: 1.4
      • Asians: 0.3
      • American Indians/Alaska natives: 2.1
      • Native Hawaiians/Pacific Islanders: 1.6
      • Multirace: 0.6

  • Predominant sex: male (90%) > female (10%) (3)[A]
  • Greatest increase in MSM (3)[A]

Etiology and Pathophysiology

T. pallidum enters through intact mucous membranes or breaks in skin. The organism quickly enters the lymphatics to cause systemic disease. Highly infectious; exposure to as few as 60 spirochetes is associated with ~50% chance of infection.

Risk Factors

MSM, multiple sexual partners, exposure to infected body fluids, IV drug use, transplacental transmission, adult inmates, high-risk sexual behavior, HIV-positive

General Prevention

Education regarding safe sex; condoms reduce but do not eliminate transmission (4)[A].

Commonly Associated Conditions

HIV infection, hepatitis B, other STIs

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Stephens, Mark B., et al., editors. "Syphilis." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2019. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116584/all/Syphilis.
Syphilis. In: Stephens MB, Golding J, Baldor RA, et al, eds. 5-Minute Clinical Consult. 27th ed. Wolters Kluwer; 2019. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116584/all/Syphilis. Accessed March 24, 2019.
Syphilis. (2019). In Stephens, M. B., Golding, J., Baldor, R. A., & Domino, F. J. (Eds.), 5-Minute Clinical Consult. Available from https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116584/all/Syphilis
Syphilis [Internet]. In: Stephens MB, Golding J, Baldor RA, Domino FJ, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2019. [cited 2019 March 24]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116584/all/Syphilis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Syphilis ID - 116584 ED - Stephens,Mark B, ED - Golding,Jeremy, ED - Baldor,Robert A, ED - Domino,Frank J, BT - 5-Minute Clinical Consult, Updating UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116584/all/Syphilis PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -