AUTOANTIBODIES: FREQUENCY (%) OF AUTOANTIBODIES IN RHEUMATIC DISEASES

AUTOANTIBODIES: FREQUENCY (%) OF AUTOANTIBODIES IN RHEUMATIC DISEASES.1
ANA Anti- dsDNA Rheumatoid Factor Anti-Sm Anti-SS-A Anti-SS-B Anti-SCL-70 Anti-Centromere Anti-Jo-1 ANCA Anti-CCP
Rheumatoid arthritis 30–60 0–5 70 0 0–5 0–2 0 0 0 0 70-80
Systemic lupus erythematosus 95–100 60 20 10–25 15–20 5–20 0 0 0 0–1 30-702
Sjögren syndrome 95 0 75 0 65 65 0 0 0 0 0
Diffuse scleroderma 80–95 0 30 0 0 0 33 1 0 0 0
Limited scleroderma (CREST syndrome) 80–95 0 30 0 0 0 20 50 0 0 0
Polymyositis/dermatomyositis 80–95 0 33 0 0 0 0 0 20–30 0 0
Granulomatosis with polyangiitis 0–15 0 50 0 0 0 0 0 0 93–961 0
1Frequency for generalized, active disease.2 Frequency for SLE with deforming erosive arthritis.
Anti-dsDNA = anti-double-stranded DNA antibody; ANA = antinuclear antibodies; ANCA = antineutrophil cytoplasmic antibody; Anti-CCP = antibodies to cyclic citrullinated peptide; Anti-Jo-1 = antibodies directed against histidyl-tRNA synthetase; Anti-Sm = anti-Smith antibody; Anti-SCL-70 = anti-scleroderma antibody; Anti-SSA = antibodies to Ro (SSA) cellular ribonucleoprotein complexes of two types (52 kDa and 60 kDa); Anti-SSB = antibodies to La (SSB) cellular ribonucleoprotein complexes; CREST = C alcinosis cutis, R aynaud phenomenon, E sophageal motility disorder, S clerodactyly, and T elangiectasia.
Reproduced with permission from Papadakis MA, McPhee SJ, Rabow MW (editors). Current Medical Diagnosis & Treatment 2016, 55th ed., McGraw-Hill, 2016.
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