Thrombocytopenia

Etiology

Decreased production (bone marrow disorder)

  • Aplastic anemia
  • Hematologic malignancies
  • Myelodysplastic syndrome
  • Megaloblastic anemia
  • Chronic alcoholism
  • Other infiltrative process, e.g., myelofibrosis, infection
Increased destruction
  • Immune disorders
    • Idiopathic thrombocytopenic purpura
    • Drug-induced, e.g., heparin, sulfonamides, thiazides, quinine
    • Secondary (chronic lymphocytic leukemia, systemic lupus erythematosus)
    • Posttransfusion purpura
  • Disseminated intravascular coagulation
  • Thrombotic thrombocytopenic purpura
  • Hemolytic uremic syndrome
  • Sepsis
  • Viral infections, AIDS
  • Liver failure
  • Preeclampsia-eclampsia
Splenic sequestration

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