Involuntary weight loss

DDx

Medical

  • Malignancy
  • Gastrointestinal disorders, eg, malabsorption, pancreatic insufficiency, peptic ulcer
  • Hyperthyroidism
  • Chronic heart, lung, or renal disease
  • Uncontrolled diabetes mellitus
  • Intestinal ischemia
  • Dysphagia
  • Anorexia due to azotemia
  • Hypercalcemia
  • Tuberculosis
  • Subacute bacterial endocarditis
Psychosocial
  • Depression
  • Dementia
  • Alcoholism
  • Anorexia nervosa
  • Loss of teeth, poor denture fit
  • Social isolation
  • Poverty
  • Inability to buy or prepare food
Drug related
  • NSAIDs
  • Antiepileptics
  • Digoxin
  • SSRIs

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