Neuro: ENCEPHALOPATHY (if co-infected with ), headache, dizziness, paresthesia
Misc: chills, fever, lymphadenopathy
* CAPITALS indicate life-threatening. Underline indicate most frequent.
PO (Adults and Children ≥12 yr): 8 mg as single dose.
Availability (generic available)
Tablets: 2 mg
Assess for signs and symptoms of Mazzotti reaction of skin (pruritus, rash, urticaria), eyes (conjunctivitis, eye pain, eye pruritus, eyelid swelling, blurred vision, photophobia, changes in visual acuity, hyperemia, ocular discomfort, watery eyes), and systemic reactions (headache, fever, hypotension, tachycardia, edema, lymphadenopathy, arthralgia, myalgia, chills, paresthesia, asthenia). Usually occur and resolve during 1st wk after dose of moxidectin. Treat symptomatically with oral hydration, recumbency, antihistamines and/or analgesics. May use IV 0.9% NaCl, and/or parenteral corticosteroids to treat orthostatic hypotension.
Assess for symptomatic orthostatic hypotension (inability to stand without support after lying down for 5 minutes) following dose. Usually transient occurring Days 1 and 2 after dose. Manage by having patient lie down until symptoms resolve.
Assess for edema and worsening onchodermatitis (pruritus, unilateral leg or forearm swelling, rash, eye symptoms) after therapy. Treat symptomatically.
Lab Test Considerations:
Monitor for Mazzotti reactions after therapy. May cause eosinophilia, eosinopenia, lymphocytopenia, neutropenia, and ↑ALT, AST, gamma glutamyl transferase (GGT) and LDH. May also cause proteinuria.
Conduct screening for loiasis before therapy in patients with exposure to Loa loa-endemic areas to decrease risk of encephalopathy.
PO Administer 4 tablet as a single dose without regard to food.
Instruct patient to take moxidectin as directed.
Advise patients that if they feel dizzy or lightheaded after taking moxidectin tablets, they should lie down until the symptoms resolve.
Advise patient that flu like symptoms (malaise, myalgia, headache, tachycardia, hypotension, pruritus) may occur during 1st wk after treatment.
Advise patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Inform patient that moxidectin does not kill adult O. volvulus and follow up evaluation is usually required.
Reduction in skin microfilarial density.
moxidectin is a sample topic from the Davis's Drug Guide.
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