Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.
Sleep disorders (including insomnia, jet lag and circadian rhythm disorders)
Melatonin is a hormone secreted from the pineal gland in a 24-hour circadian rhythm, regulating the normal sleep/wake cycle. As a supplement, melatonin has both phase-shifting and sleep-promoting properties. In addition to promoting sleep, physiologic roles of melatonin include regulation of the secretion of growth hormone and gonadotropic hormones. It also possesses antioxidant activity.
Improved sleep pattern.
Metabolism and Excretion: Unknown
Use Cautiously in:
CNS: drowsiness, headache, dizziness
GI: nausea, vomiting, abdominal cramps
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
Natural Drug Interaction
PO (Adults): 0.3–10 mg daily at bedtime.
Tablets: 3 mg
Lab Test Considerations:
Monitor blood glucose, coagulation panel, hormone panel, and lipid panel periodically during therapy.
Relief of insomnia.
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