Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.
Sage leaf and volatile oil contain active constituents that have antioxidant, CNS depressant, estrogenic, anti-inflammatory and anticholinesterase activity. It may also have hypoglycemic activity. Sage also contains camphor which can cause neurotoxicity and hepatotoxicity in high doses.
Improved cognitive function in Alzheimer's disease.
Metabolism and Excretion: Unknown
Use Cautiously in:
CNS: dizziness, agitation, seizures (high doses)
GI: nausea, vomiting, abdominal pain, hepatotoxicity (high doses)
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
Natural Drug Interaction
PO: (Adults) Alzheimer's disease–1 gram/day of extract.
Topical: (Adults) Herpes labialis–apply cream with 23 mg/gram of sage extract every 2–4 hours while awake starting within 1 day of the first symptoms and continuing for 10 to 14 days.
Cream : 23 mg/gram sage extract in combination with rhubarb extract
Lab Test Considerations:
Monitor: blood glucose periodically during therapy.
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