Symptomatic relief of non-infectious diarrhea in HIV-infected patients currently receiving antiretroviral therapy.
A natural product derived from Croton lechleri , a species of flowering plant.
Inhibits cyclic adenosine monophosphate (cAMP)-stimulated cystic fibrosis transmembrane conductance regulator (CTFR) chloride ion channels and the calcium-activated chloride channels on luminal membranes of enterocytes. Blocks chloride secretion and water loss by inhibiting chloride channels on the membranes of enterocytes.
Decreased incidence and severity of diarrhea.
Absorption: Minimal absorption following oral administration.
Metabolism and Excretion: Unknown.
Lactation: Breastfeeding should be avoided in patients with HIV.
Use Cautiously in:
Infectious causes of diarrhea (evaluate and treat prior to use);
OB: Safety not established in pregnancy;
Pedi: Safety and effectiveness not established in children.
Adverse Reactions/Side Effects
GI: abdominal distention, flatulence, hemorrhoids, nausea, ↑ liver function tests
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