Sodium picosulfate– converted by colonic bacteria to BHPM, which directly stimulates colonic peristalsis. Magnesium oxide and anhydrous citric acid– combine to form magnesium citrate, an osmotic laxative that causes water retention within the GI tract.
With concurrent fluid ingestion produces watery diarrhea and colonic purging in preparation for colonoscopy.
Concurrent use of drugs affecting fluid and electrolyte status/renal function including ACE inhibitors, angiotensin receptor blockers, corticosteroids, NSAIDs, diuretics, and other laxatives may ↑ risk of dehydration, renal impairment, seizures, hypotension, and fluid/electrolyte abnormalities.
Concurrent use of medications that ↓ seizure threshold, including tricyclic antidepressants or concurrent alcohol / benzodiazepine withdrawal (may ↑ risk of seizures).
Absorption of oral medications taken within 1 hr of start may be altered.
Prior/concurrent anti-infectives may ↓ efficacy.
Concurrent use of other laxatives (may ↑ risk of mucosal ulcerations).
Concurrent of use of digoxin (electrolyte abnormalities may ↑ risk of toxicity).
Concurrent use of drugs that may induce the syndrome if inappropriate secretion of antidiuretic hormone (SIADH) including antipsychotics, carbamazepine, tricyclic antidepressants, and SSRIs may ↑ risk of water retention and electrolyte abnormalities.
Assess patient for abdominal distention, presence of bowel sounds, and usual pattern of bowel function.
Assess color, consistency, and amount of stool produced. Watery diarrhea to clear liquid should be defecated at the completion.
Monitor for significant vomiting or signs of dehydration (orthostatic hypotension) following medication. Consider post-colonoscopy lab tests (electrolytes, serum creatinine, BUN) and treat accordingly. May occur up to 7 days after colonoscopy.
Assess for seizures, especially in patients with a seizure disorder or patients taking medications that lower seizure threshold, withdrawing from alcohol or benzodiazepines, or with hyponatremia.
Monitor ECG pre-dose and post-colonoscopy in patients with increased risk of arrhythmias (history of prolonged QT interval, uncontrolled arrhythmias, recent MI, unstable angina, HF, cardiomyopathy).
Lab Test Considerations:
May cause ↓ serum potassium, sodium, chloride, calcium, eGFR, and ↑ serum magnesium and creatinine.
Correct fluid and electrolyte abnormalities prior to therapy.
Assess for difficulty swallowing or history of regurgitation or aspiration prior to administering.
PO Clenpiq is ready to drink and dose not need to be diluted. Solution is clear with possible presence of visible particles. One bottle of Clenpiq is equal to one dose. Take bottle the night before colonoscopy followed by five 8-oz drinks (upper line of dosing cup) of clear liquid within 5 hr and before bed. On day of colonoscopy, second bottle followed by at least four 8-oz drinks of clear liquid before colonoscopy. Drinking clear liquids may continue until 2 hr of colonoscopy.
Instruct patient to consume only clear liquids (no solid food or milk) on the day before colonoscopy and up to 2 hr before time of the colonoscopy. Reconstitute powder as directed and follow dosing regimen.
Caution patient to hydrate adequately with clear liquids before, during, and after use. Clear liquids include water, clear broth, apple juice, white cranberry juice, white grape juice, ginger ale, plain jello (not red or purple), and frozen juice bars (not purple or red). Do not eat solid foods or drink milk or alcohol during therapy.
Advise patient to notify health care professional if severe bloating, distention, or abdominal pain occurs following first bottle. Delay administration of second bottle administration until symptoms resolve.
Advise patient not to take any other laxatives during therapy.
Instruct patient to notify health care professional promptly if hives, rash, vomiting that prevents you from keeping down the additional prescribed amounts of clear liquids needed after taking medication, dizziness, urinating less than normal, or headache occur.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.