Osteoporosis and Osteopenia
Basics
Basics
Basics
Description
Description
Description
A metabolic bone disease characterized by low bone mass, with deterioration of bone microarchitecture leading to compromised bone strength and increased risk of fragility fracture
Epidemiology
Epidemiology
Epidemiology
Prevalence
- 10.2 million Americans have osteoporosis (1).
- >43.3 million Americans have low bone mass (1).
- Women >50 years of age: osteoporosis 19.6% and osteopenia 51.5%
- Men >50 years of age: osteoporosis 4.4% and osteopenia 33.5%
Etiology and Pathophysiology
Etiology and Pathophysiology
Etiology and Pathophysiology
Imbalance between bone resorption and formation results in a net loss of bone mass and density over time, leading to weakened and porous bones.
Genetics
- Familial predisposition
- More common in Caucasians and Asians than in African Americans and Hispanics
Commonly Associated Conditions
Commonly Associated Conditions
Commonly Associated Conditions
- Malabsorption syndromes: gastrectomy, inflammatory bowel disease, celiac disease
- Hypoestrogenism: menopause, hypogonadism, eating disorders, etc.
- Endocrinopathies: hyperparathyroidism, hyperthyroidism, hypercortisolism, diabetes mellitus
- Hematologic disorders: sickle cell disease, multiple myeloma, thalassemia, hemochromatosis
- Many other chronic diseases including end-stage renal disease
- Medications: chemotherapy agents, antiepileptics, aromatase inhibitors (raloxifene), chronic corticosteroids (equivalent to at least 5 mg of prednisone daily for at least 3 months), medroxyprogesterone acetate, heparin, SSRIs, thyroid hormone (in supraphysiologic doses), PPIs
There's more to see -- the rest of this topic is available only to subscribers.
© 2000–2025 Unbound Medicine, Inc. All rights reserved