Dupuytren Contracture
BASICS
BASICS

BASICS
DESCRIPTION
DESCRIPTION
DESCRIPTION
- Palmar fibromatosis is caused by progressive fibrosis of the palmar fascia, leading to flexion deformities and functional loss.
- Distinct from “trigger finger,” which results from thickening of the distal flexor tendon.
- Similar change rarely occurs in plantar fascia, usually appearing simultaneously.
- System(s) affected: musculoskeletal
- Dupuytren diathesis is an aggressive heritable form associated with age of onset <40 years, bilateral presentation to include radial digits, plantar fibromatosis (Ledderhose disease), and penile fibromatosis (Peyronie disease) (1).
- Synonyms: morbus Dupuytren; Dupuytren disease; “Celtic hand”; Viking disease; palmar fascial fibromatosis, contracture of palmar fascia
EPIDEMIOLOGY
EPIDEMIOLOGY
EPIDEMIOLOGY
Prevalence
Prevalence
Prevalence
- Increases with age; mean prevalence in western countries: 12%, 21%, and 29% at ages 55, 65, and 75 years, respectively; Norway: 30% of males aged >60 years; Spain: 19% of males aged >60 years
- More common in Caucasian men of Scandinavian or Northern European ancestry
- Mean age of onset is 60 years with typical age-range of onset between 40 and 80 years.
ETIOLOGY AND PATHOPHYSIOLOGY
ETIOLOGY AND PATHOPHYSIOLOGY
ETIOLOGY AND PATHOPHYSIOLOGY
- Definitive etiology unknown; possibly oxidative stress, altered wound repair, and/or abnormal immune response
- Progresses through three stages (Luck classification) (1):
- Proliferative phase: proliferation of myofibroblasts with thickening of the palmar fascia and nodule development on palmar surface
- Involutional stage: Myofibroblasts spread along palmar fascia to fingers with cord development via production of more type 3 collagen.
- Residual phase: Fibroblasts are predominant with dense collagen leading to cord tightening and contracture flexion formation.
Genetics
Genetics
Genetics
- Autosomal dominant inheritance with incomplete penetrance:
- Siblings with 3-fold risk
- 68% of male relatives of affected patients develop disease at some time.
- Possible association with HLA alleles
RISK FACTORS
RISK FACTORS
RISK FACTORS
- Smoking (mean 16 pack-years, odds ratio: 2.8)
- Increasing age
- Male/Caucasian; male > female (range 3.5:1 to 9:1)
- Vibration exposure and manual work—risk doubles if regular (weekly) exposure
- Diabetes mellitus (DM) (increases with duration of DM, usually mild; middle and ring fingers are involved)
- Excessive alcohol consumption
- Cirrhosis
- Northern European ethnicity
- Family history
- Hand trauma
- Low body weight and BMI
COMMONLY ASSOCIATED CONDITIONS
COMMONLY ASSOCIATED CONDITIONS
COMMONLY ASSOCIATED CONDITIONS
- Alcoholism
- Epilepsy (inconstant data)
- DM, particularly type 1 DM
- Chronic lung disease
- Occupational hand trauma (vibration)
- Hypercholesterolemia
- Carpal tunnel syndrome
- Peyronie disease
- HIV
- Cancer
- Adhesive capsulitis of shoulder
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